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Medicinal Chemistry

  1. Define pharmacological model. What is the purpose of pharmacokinetic models? Draw and explain a catenary model.
  2. Describe the significance of measuring plasma drug concentration of a patient assuming you are a clinical pharmacist.
  3. What do you mean by volume of distribution at steady-state ? How can you determine it from two compartment open model?
  4. A new antibiotic was given in a single intravenous bolus of 4 mg/kg to five healthy male ',c!unteers in the age from 23 to 38 years (average weight 75 kg). The ehcrrrccokinetics of this antibiotic followed one compartment open model ad fits The following equation- C =7Se .2461 Assume p g/ml for C1, and hr for t. Now determine i) t,,2 ii) Vd iii) plasma level of the antibiotic after 4 hours and iv) when the plasma level of the antibiotic declines to less that 2 ,i/ g/m1 assuming the drug is no longer effective, when the next dose
  5. should be administered?
  6. After giving a single oral dose, the rate of change in amount of drug in body is dependent on the relative rates of aborption and elimination following one compartment open model-Explain it.
  7. Following first order absorption model, "the time needed to reach the maximum concentration  is independent of dose of the drug but is dependent on the rate constants for absorption and culmination"-Prove it.
  8. Describe the significance of absorption rate constant.
  9. After an oral dose of 10 mg benzodiazepine tablet to a patient the plasma samples were collected. By feathering technique the absorption rate constant K„ and culmination rate constant k were determined 0.3 hr-1 and 0.1 hr-1, respectively. The intercept on the y axis was observed 60 ng/ml. If 80% the drug is absorbed, determine the elimination half-life and  volume of distribution (V1) of the drug to the patient.

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