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Bio-pharmaceutics



  1. Mention the salient features of two compartment open model.
  2. Derive a relationship between clearance and area under curve. "Clearance is used to calculate concentration at steady-state"-Explain with example.
  3. Mention the differences between rate method and sigma-minus method.
  4. What are the shortcomings of compartmental analysis? How does a mammillary model differ from a catenary model?
  5. A drug was given in a single intravenous does of 200 mg to an 80-kg adult male patient. After 6 hours.Plasma drug concentration was 1.5 mg. dL. Assuming that the apparent volume of distribution is 20% of body weight, calculate the total amount of drug to be present in the body fluid after 6 hours. What is the elimination half life of the drug? 
  6. C av is not the arithmetic mean of maximum and minimum concentrations at steady-state during MDR-Illustrate it with proper example. What do you mean by degree of fluctuation?
  7. What is the basic Principle of residual technique? How an this technique be applied to explain the graph for two compartment open model?
  8. What do you mean by open model and closed model? Derive an equation to calculate concentration of drug at time t that follows one compartment open model and is given intravenously.
  9. What do you mean by principle of superposition? How can apply this principle to calculate Cp during MDR given intravenously?
  10. What will be the values (If the maintenance dose is 1000 mg) for D'inclx,D" min and D"av during MDR given intravenously when: i) T = 12t112 ii) T =1-112 iii) T =1.5t1,,
  11. What is intermittent infusion? How does if differ from continuous infusion? Mention the important features of continuous infusion curve.
  12. A patient was infused for 6 hours with a drug 0.01/hr; Vd.= 10 L) at a rate of 2 mg/hr. What is the concentration of the drug in the body 3 hours after cessation of infusion?

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